Because obesity masks the need for screening, there is no previous description of dyslipidemia in healthy normal-weight children. The aims of this study were a) to determine the prevalence of disorders in lipid profile among non-obese prepubertal children, and b) to establish its association with the family history (FH) of high blood pressure (HBP), type 2 diabetes (T2-DM), and obesity.A random sample of 439 healthy normal-weight children, 218 girls and 221 boys, aged 10-13 years and Tanner stage 1-2 were enrolled in a community-based cross-sectional study carried out in Durango, in northern Mexico. For verifying accuracy of FH, a direct detailed medical history including anthropometric and laboratory measurements was directly obtained from both parents.Among parents, prevalence (95% CI) of T2-DM, HBP, and obesity was 8.3% (3.5-14.3), 14.2% (8.6-24.6), and 28.5% (24-33), and for hypercholesterolemia, low HDL-cholesterol, high LDL-cholesterol, hypertriglyceridemia, and mixed hyperlipidemia 17.9 % (15-20), 27.8% (25-30), 14.3% (12-16), 32.3% (29-35), and 9.8 % (8-12), respectively. Among children, prevalence (95% CI) for high total cholesterol, low HDL-cholesterol, high LDL-cholesterol, isolated hypertriglyceridemia, and mixed hyperlipidemia was 15.9% (12.6-19.5); 6.2% (4.0-8.5); 14.6% (11.4-18.0); 9.3% (6.7-12.2); and 3.6% (2.1-5.8), respectively. Sex- and birth weight-adjusted odds ratio (95% CI) showed that FH of T2-DM, but not of HBP and obesity, was associated with hypercholesterolemia (2.1; 1.2-6.2), low HDL-cholesterol (1.8; 1.1-5.7), and hypertriglyceridemia (2.3; 1.1-6.4).Non-obese children in this sample display a high prevalence of abnormalities in lipid profile associated with FH of T2-DM.