The aim of this study was to ascertain the effect size of statins in modulating plasma uric acid concentrations.A search was undertaken of the MEDLINE, SCOPUS, Web of Science and Google Scholar electronic databases.Studies meeting the following criteria were included: (i) randomized controlled trials with either a parallel or crossover design; (ii) investigated the impact of statin therapy on plasma uric acid concentrations; and (iii) presentation of sufficient information on uric acid values at baseline and at the end of follow-up in each group, or presenting the net change.The present meta-analysis suggested a significant reduction in plasma uric acid levels following statin therapy; however, this does not seem to be a class effect as subgroup analysis revealed a significant reduction with atorvastatin and simvastatin only, and not with pravastatin and rosuvastatin.Atorvastatin and simvastatin, but not the other statins, can reduce serum uric acid levels.