We evaluated the contribution of the semicircular canals to autonomic responses to rotation in 12 normal subjects and three labyrinthine defective patients. Respiration, heart rate, arterial blood pressure and blood flow in the finger were recorded during 60 degrees /s steps of constant velocity rotation. Rotation was performed in the dark about a vertical axis: (I) with head upright for yaw stimulation of horizontal canals; (II) head tilted chin down and rotated laterally to stimulate the vertical canals in both face-forwards and backwards directions. In normal subjects, rotation in the pitch plane elicited an increase in respiratory frequency due to a shortening of the time for expiration, whilst patients had inconsistent responses. We conclude that vertical semicircular canal activity exerts a regulatory drive on respiration in human subjects.