This syndrome is characterized by necrohemorrhage of the adrenal glands in the course of a serious infectious disease, which is characterized by septic shock with multiple organ failure (prevailing neurological, renal and hematological failure even with criteria for disseminated intravascular coagulation), disseminated purpura and data on acute adrenal insufficiency. Initially described by an English physician in 1911, Dr. Rupert Waterhouse and later studied further by a Danish pediatrician, Dr. Carl Friderichsen in 1917 [1-3]. Within the etiology, it is mentioned that more than 90% of the cases are due to infectious agents, the rest to hematological pathologies or to certain added drugs. Of the infectious agents, Neisseria meningitidis is mentioned as responsible for 75-80% of the cases, the rest is distributed in a wide range of bacterial and rarely viral agents. In immunocompromised patients, the cases associated with cytomegalovirus that are hungry for the adrenal glands stand out. In a series of 5 postmortem cases, the presence of coagulase negative staphylococci was evidenced