Depression is a mental health problem in elderly people; it is estimated that at least 30% suffers from it. Retired people face the transition from adult to elder and from working to retire, which is a significant change that can lead to mental disorders. The research was carried out with the objective of evaluating the preparation program for the retirees of the IMSS as a preventive strategy for depression in adults. It is a quasi-experimental design with measurements before-after where the independent variable (pre-retirement program) has been introduced with a comparison group. The IMSS pre-retirement program encourages the future retiree to adopt a positive attitude; it encourages the employees to build a life project that promotes healthy aging, hence preventing the onset of depression. However, it is necessary the diagnosis of depression to be made, and then get treatment and follow-up, because the program is not capable of influencing in mild, moderate or severe depression.Finally, even when there is an incidence of abuse in the elderly, this topic is not discussed in the preretirement program, therefore the opportunity to prevent and detect it is lost.