This review presents the studies on Salmonella conducted by three research groups in Mexico. Each of these groups belongs to different but complementary disciplines. The need for continuous epidemiological surveillance of Salmonella throughout the food chain, in conjunction with molecular typing of the isolates is discussed. The epidemiological and molecular findings should serve as the basis for a national or regional control program that includes the development of specific vaccines. The information can also be used to develop rapid and specific diagnostic tests.