Duodenal atresia is a rare disorder occurring in 1 in 10,000 live births. Duodenal atresia is associated with trisomy 21: 5-15% of trisomy 21 cases have duodenal atresia and 30% of duodenal atresia cases are associated with trisomy 21. Some cases of duodenal atresia may be recurrent. Two siblings were born with duodenal atresia but no other anomalies. The father of the siblings also had isolated congenital duodenal atresia. Recurrent duodenal atresia should be considered when the condition is discovered prenatally. The etiology may be autosomal dominant inheritance, as with Feingold syndrome, or autosomal recessive inheritance.