ABSTRACT By Western blotting, we demonstrate high-level expression of NRAMP1 proteins in peripheral blood cells and granulomas ofMycobacterium bovis-infected bovines. Immunohistochemistry of granulomatous lesions showed heavily labeled epithelioid macrophages and Langhans cells. These data suggest that M. bovisinfection enhances NRAMP1 expression and that active tuberculosis can occur despite this response.