Introduction: chronic kidney disease represents a public health problem with a worldwide prevalence of 697 million cases and a high cardiovascular risk that increases mortality. Renal transplantation improves cardiac function with an increase in left ventricular ejection fraction, reduction of ventricular hypertrophy among others, which impacts survival. Echocardiography is a practical tool available for the detection of these cardiac changes before and after renal transplantation. Objective: to determine the short, medium and long term impact of renal transplantation on cardiac function measured through echocardiography and electrocardiography in transplanted patients in High Specialty Medical Unit (UMAE) Specialty Hospital No. 14 of Veracruz. Material and methods: longitudinal and descriptive study, in patients with renal transplantation divided into 3 groups: group I: six months post-transplantation, group II: 12 months post-transplant, group III: 24 months post-transplant. Evaluating cardiac function with echocardiography and electrocardiogram before and after the procedure (6, 12 and 24 months). Results: 62 patients were included, with the following distribution: group I: 7 patients, group II: 20 patients and group III: 35 patients. The overall mean age was 33.9 ± 10.26 years. Male sex corresponded to 67.7% of the population. There were no significant differences in demographic, biochemical, electrical or echocardiographic characteristics between the three groups. In the post-transplantation electrocardiogram analysis, the Gubner, Sokolow and Cabrera criteria did not show a reduction in LVH in the three groups. The reduction in LVH documented by the Lewis index was significant only up to two years, p = 0.004. It was observed post-transplant that SIV and PP were significantly reduced in group I (p = 0.03 and p = 0.047 respectively), maintaining this reduction at 12 months and two years (p = 0.00 both). Changes in GPR were only modified in group II and group III (p = 0.000). Similar findings are observed in these two groups with LV mass index (p = 0.00) and PSAP (p = 0.00). No changes in systolic diameter or LVEF were observed in the three groups. Diastolic diameter was reduced only up to two years, p = 0.027. Conclusions: patients undergoing renal transplantation have improvement in cardiac function observed by a significant reduction in left ventricular hypertrophy and PSAP from 6, 12 and 24 months, with an impact on control of arterial hypertension.