Background There have been antidiabetic claims for Aloe vera (AG) Barbadensis Mill. gel and infusion of Cnidoscolus chayamansa (CC) McVaugh. Objectives To determine if the ingestion of total process AG concentrated 5:1 (TA), AG, CC or placebo can reduce hyperglycemia in women with early metabolic syndrome (EMS). Methods One hundred-twenty five women from two outpatient university clinics were randomly assigned to a three assay double-blind crossover procedure. Subjects were adult women with EMS by ATP III criteria assigned to assay 1: AG&CC vs P1&P2; assay 2: AG&P2 vs P1&CC; or assay 3: TA vs P3. All assays included the ingestion of one, then zero (washout period), then two gelatins/day, for 4, 1, 4 weeks, respectively. The expected outcome was an HbA1c decrease ≥4.2 mmol/mol or lower but sustaining euglycemia. Results Participants had a mean age of 46.8 ± 9.7 years and a mean HbA1c of 47.8 ± 12.7 mmol/mol at the start of the study. The least tolerated combination was AG&P2. Patients complained of bad taste and mild stomach pain because of the double dose of this treatment; this caused withdrawals: 4/25 vs. 9/21, respectively, Chi square = 4.1, df = 1, P < 0.05. Changes in HbA1c (mmol/mol) were assay 1, −1.8 ± 7.5 vs −1.6 ± 6.9, P > 0.05; assay 2, −1.3 ± 6.6 vs −1.4 ± 7.6, P > 0.05; assay 3, −4.9 ± 8.3 vs 0.44 ± 5.4, P < 0.01, respectively. TA concomitantly reduced high-sensitive C-reactive protein (hs-CRP) (P < 0.05). Conclusions Data suggest that TA decreases blood glucose levels by reducing the proinflammatory state. The infusion of microwave dehydrated CC leaves did not reduce blood glucose or HDL and triglyceride levels.