Introduction: Diabetes mellitus is a global public health problem, millions of deaths per year are directly related to this condition and it is the fourth leading cause of death from disease. The increase in causes for type 2 diabetes reflects a lifestyle adopted by people and without referred prevention strategies therefore constitute a priority objective of therapeutic and educational interventions. Objective: To evaluate the clinical and biochemical parameters in the patients of the diabetic patient care program at the beginning, end and one year after completion. Material and methods: Retrospective cohort in a Primary Health Care Unit in Cancun, Mexico in adults who completed the diabetic patient care program called Diabet IMSS. Records of diabetic patients from the Diabet IMSS program were obtained and evaluated: Glucose, HbAc1, Total cholesterol, Triglycerides, Blood pressure and BMI at the beginning, end and one year after finished the program. The information was analyzed by t student for related samples. Results: 195 records of patients with a mean age of 58 ± 10.5 years and 10 ± 5.8 years of diabetes evolution. At the end of the program, HbA1c, Glucose and triglycerides showed a decrease (p < 0.05) but, other evaluated parameters showed no difference. After one year of the end of the program, a significant increase (p < 0.05) was reported in all the clinical and biochemical parameters evaluated. Conclusions: The improvement reached at the end of the Diabet IMSS program corresponds to significant descends results in some variables; although finally, the control goals are not reached. However, the patients did not manage to maintain the improvements reached at the end of the program, registering a considerable increase of all clinical variables one year after finished.