Coronavirus disease (COVID-19) caused by SARS-CoV-2, has been a pandemic that has affected millions of people worldwide, which after infection is capable of leaving significant sequelae, currently known as post-COVID-19 syndrome. On the other hand, Hereditary Hemorrhagic Telangiectasia (HHT), also called Rendu-Osler-Weber (ROW) syndrome, is a multisystemic vascular disorder characterized by arteriovenous malformations and mucocutaneous telangiectasias that clinically manifest with spontaneous epistaxis, gastrointestinal bleeding, among others. Material and Methods: This case report describes a patient with Rendu-Osler-Weber syndrome who, after infection with SARS-CoV-2, developed massive hemorrhagic complications (hypovolemic shock) that had not been present during the course of her disease. Discussion: It is important to keep in mind that SARS-CoV-2 infection in patients with Rendu Osler Weber syndrome leads to an increased risk of massive bleeding; however, this association is not yet well established, so this clinical case describes this phenomenon