Introduction: Diffuse large B-cell non-Hodgkin’s lymphoma is the most frequent subtype of non-Hodgkin’s lymphomas worldwide. It accounts for 30-40% of cases [1,2]. Splenic infarcts manifest with painful abdo Material and Methods: The case of a 35-year-old man is discussed. The patient reports abdominal pain in the epigastrium with an intensity of 10/10, leukocytosis at 20,000, normal amylase and lipase; on USG pancreatitis is suspected. A CT scan showed splenic and hepatic abscess, free fluid and pleural effusion. He presented splenic infarction. The histopathological study after splenectomy reported: infiltration by cells of atypical lymphoid appearance, immunohistochemistry: CD20 +, Cd3 -, CD15 - , CD 30 -. IPI 1 Ann Arbor I. Treatment is started with R-CEOP x 6 cycles and the patient showed complete remission. We looked for the association between non-Hodgkin’s lymphoma of large B cells in young patients with splenic infarction, the frequency of abdominal pain and survival.The results were that, of 30,455 Ann Arbor stage I patients with large cell non-Hodgkin’s lymphoma, 470 cases had spleen involvement (1.5%) [4], 613 patients had splenic involvement (6.3%) [5]; the most common manifestation was abdominal pain (30%) and survival was 48% at 100 months when limited to the spleen (HR=0.62,95% CI=0.53-0.86,p