Introduction: Overweight and obesity are a public health problem, which continues to increase in recent decades and is associated with chronic diseases. NutrIMSS is a strategy of the Mexican Institute of Social Security (IMSS) that promotes a healthy lifestyle and provides education to patients on proper nutrition, water consumption and practice of physical activity. Objective: To evaluate the impact of an educational strategy on clinical and biochemical indicators in overweight or obesity patients. Materials and methods: Descriptive, longitudinal and prospective study in patients of the Family Medicine Unit No. 80 from Morelia Michoacán, Mexico, with diagnosis of overweight or obesity, through an educational strategy based on NutrIMSS strategy, that included: Three educational sessions, nutritional care and inclusion to the social security center for regular physical activity. Anthropometric and biochemical measurements were taken at month 0 and at month 6, March-August 2017, participants who did not fulfill 80% of the NutrIMSS strategy assistance were excluded. The data are presented whit mean ± standard deviation, t-student related samples, statistical significance: p < 0.05. Results: 30 patients, 67.7% women. Pre-intervention and post-intervention anthropometric parameters: Weight (Kg): 80.82 ± 12.67, 78.86 ± 12.36 (0.002), BMI (kg/m2 ): 30.40 ± 3.93, 29.59 ± 3.83 (0.001), abdominal waist (cm): 97.38 ± 12.28, 96.41 ± 12.04 (0.009), systolic blood pressure (mmHg): 117 ± 6.90, 114 ± 7.24 (0.001), diastolic blood pressure (mmHg): 76 ± 5.57, 74.70 ± 5.71 (0.096), glucose (mg/dl): 94.20 ± 12.35, 89.70 ± 10.56 (0.009), total cholesterol (mg/dl): 164.47 ± 29.01, 152.40 ± 30.80 (0.012), High density lipoprotein (mg/dl): 52 ± 13.07, 44.20 ± 11 (0.001), Low density lipoproteins (mg/dl): 84.90 ± 19.62, 87.70 ± 19.46 (0.321) and triglycerides (mg/dl): 127.70 ± 41.58, 119.20 ± 36 (0.215). Conclusion: There is a positive impact of the educational strategy on clinical/biochemical values in overweight and obese patients.