Rubus liebmanii is used in Mexican traditional medicine to treat cough, nervous conditions, insomnia and dysentery. There are not biological and chemical reports from this specie; however, in other species of the genus, many compounds with important biological activity have been isolated. The ethanolic extract of aerial parts showed antiprotozoal activity against Entamoeba histolytica, Trychomonas vaginalis and Giardia lambia, with values nhibition 10, 12, and 4% at 100µg/mL, respectively. Against G. intestinalis presented an IC50 =11.75µg/mL. Low toxicological effect against Balb/c mice and Sprague-dawley rats (>5g/kg) were determined.