Dehydroepiandrosterone (DHEA) is an adrenal andro-gen precursor of sex steroids with effects on a variety of physiological events [1]. DHEA and its sulfate (DHEA-S), as well as androstendione, have minimal androgenic activity [2]. It has been reported that serum levels of DHEA and DHEA-S substantially decrease with age, and experimental studies have demonstrated benefit with DHEA substitution at physiologic doses [3]. DHEA and DHEA-S are abundant in the circulation. DHEA-S ac-counts for more than 99% of the steroid in the serum, with less than 1% of free DHEA. Their main actions have been related to cellular control, immunoregulation, obesity and lipid metabolism [2]. Estrogen and androgen replacement therapy dates to 1941, when Geist and Salmon used an-drogen therapy to treat climacteric symptoms [4]. DHEA has also been used as part of hormone therapy.